Dose
For adult the typical dose of probenecid is 250 mg twice a day for a few weeks. Some people may need high doses to completely block the excretion of uric acid.
Side effects
Probenecid is a relatively safe drug. Very rarely it may cause headaches or a warm body sensation. Wheezing and a feeling of tightness around the chest have also been reported.
This property of probenecid in blocking the excretion of drugs has often been utilized by bodybuilders to prevent excretion of anabolic steroids in the urine. What this means is that if someone takes a steroid and probenecid at the same time, the anabolic steroid will remain in the body and won’t be excreted in the urine. Thus, the steroid will not be detected in the urine.
In the past, probenecid has often been called a steroid masking agent. The drug does prevent the excretion of certain steroids into the urine and the urine test will be negative. However, probenecid itself gets into the urine and here lies the problem.
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